diff --git a/app.py b/app.py
index ff9c093..c9665fb 100644
--- a/app.py
+++ b/app.py
@@ -15,7 +15,7 @@ from werkzeug.utils import secure_filename
 import json
 from contextlib import contextmanager
 from excel_processor import ExcelProcessor
-from config import DATABASE_PATH, STATIC_PATH, TEMPLATES_PATH
+from config import DATABASE_PATH, MEDICINE_MASTER_PATH, STATIC_PATH, TEMPLATES_PATH
 
 # Flask 앱 초기화
 app = Flask(__name__, static_folder='static', template_folder='templates')
@@ -42,6 +42,10 @@ def get_db():
     conn = sqlite3.connect(app.config['DATABASE'])
     conn.row_factory = sqlite3.Row  # 딕셔너리 형태로 반환
     conn.execute('PRAGMA foreign_keys = ON')  # 외래키 제약 활성화
+    # 의약품 마스터 DB 연결 (읽기 전용 참조)
+    medicine_db = str(MEDICINE_MASTER_PATH)
+    if os.path.exists(medicine_db):
+        conn.execute(f"ATTACH DATABASE '{medicine_db}' AS med_master")
     try:
         yield conn
         conn.commit()
@@ -3768,6 +3772,73 @@ def convert_to_otc(compound_id):
     except Exception as e:
         return jsonify({'error': str(e)}), 500
 
+# ==================== 의약품 마스터 검색 API ====================
+
+@app.route('/api/medicine-master/search', methods=['GET'])
+def search_medicine_master():
+    """의약품 마스터 검색 (medicine_master.db ATTACH 활용)"""
+    try:
+        q = request.args.get('q', '').strip()
+        category = request.args.get('category', '')  # 전문일반구분 필터
+        limit = min(int(request.args.get('limit', 50)), 200)
+
+        if not q or len(q) < 2:
+            return jsonify({'success': False, 'error': '검색어는 2자 이상 입력하세요'}), 400
+
+        with get_db() as conn:
+            cursor = conn.cursor()
+
+            where_clauses = ["(m.product_name LIKE ? OR m.company_name LIKE ? OR m.standard_code LIKE ? OR m.notes LIKE ?)"]
+            params = [f'%{q}%', f'%{q}%', f'%{q}%', f'%{q}%']
+
+            if category:
+                where_clauses.append("m.category = ?")
+                params.append(category)
+
+            # 취소된 제품 제외
+            where_clauses.append("(m.cancel_date IS NULL OR m.cancel_date = '')")
+
+            params.append(limit)
+
+            cursor.execute(f"""
+                SELECT m.id, m.product_name, m.company_name, m.spec,
+                       m.total_quantity, m.form_type, m.package_type,
+                       m.item_std_code, m.category, m.representative_code,
+                       m.standard_code, m.ingredient_name_code, m.notes,
+                       m.atc_code
+                FROM med_master.medicine_master m
+                WHERE {' AND '.join(where_clauses)}
+                ORDER BY m.product_name, m.spec
+                LIMIT ?
+            """, params)
+
+            results = [dict(row) for row in cursor.fetchall()]
+
+        return jsonify({'success': True, 'data': results, 'count': len(results)})
+
+    except Exception as e:
+        return jsonify({'success': False, 'error': str(e)}), 500
+
+@app.route('/api/medicine-master/categories', methods=['GET'])
+def get_medicine_categories():
+    """의약품 마스터 카테고리 목록 (전문일반구분)"""
+    try:
+        with get_db() as conn:
+            cursor = conn.cursor()
+            cursor.execute("""
+                SELECT category, COUNT(*) as cnt
+                FROM med_master.medicine_master
+                WHERE category != '' AND (cancel_date IS NULL OR cancel_date = '')
+                GROUP BY category
+                ORDER BY cnt DESC
+            """)
+            categories = [{'name': row['category'], 'count': row['cnt']} for row in cursor.fetchall()]
+
+        return jsonify({'success': True, 'data': categories})
+    except Exception as e:
+        return jsonify({'success': False, 'error': str(e)}), 500
+
+
 if __name__ == '__main__':
     # 데이터베이스 초기화
     if not os.path.exists(app.config['DATABASE']):
diff --git a/config.py b/config.py
index 2e7579d..683a450 100644
--- a/config.py
+++ b/config.py
@@ -12,6 +12,7 @@ PROJECT_ROOT = Path(__file__).parent
 
 # 데이터베이스 경로 - 항상 절대 경로 사용
 DATABASE_PATH = PROJECT_ROOT / 'database' / 'kdrug.db'
+MEDICINE_MASTER_PATH = PROJECT_ROOT / 'database' / 'medicine_master.db'
 
 # 기타 자주 사용하는 경로들
 STATIC_PATH = PROJECT_ROOT / 'static'